Wednesday, 14 February 2018

MTS Website Revamp

The MTS website has been revamped to make it easier for our visitors to quickly find the information that they need. We've also added links to the website menu on the MTS blog. Visit the website now to find out about the training, consultancy and auditing services that we can offer.

 

Wednesday, 24 January 2018

MTS Recommends... Methods for Identifying Out-of-Trend Data in Analysis of Stability Measurements—Part II: By-Time-Point and Multivariate Control Chart

Methods for Identifying Out-of-Trend Data in Analysis of Stability Measurements—Part II: By-Time-Point and Multivariate Control Chart 

 "In Part I of this article series, the authors discussed the regression control chart method for identifying out-of-trend data in pharmaceutical stability studies. In Part II, the by-time-point method and the multivariate control chart method are investigated, and improved approaches are suggested. The method is illustrated using real data sets."

M. Mihalovits and S. Kemény, "Methods for Identifying Out-of-Trend Data in Analysis of Stability Measurements–Part II: By-Time-Point and Multivariate Control Chart," Pharmaceutical Technology 41 (12) 2017.

MTS Recommends... Methods for Identifying Out-of-Trend Data in Analysis of Stability Measurements–Part I: Regression Control Chart

Methods for Identifying Out-of-Trend Data in Analysis of Stability Measurements–Part I: Regression Control Chart 

"In Part I of this article series, the regression control chart method for identifying out-of-trend data in pharmaceutical stability studies is investigated, and an improved approach is suggested."

M. Mihalovits and S. Kemény, "Methods for Identifying Out-of-Trend Data in Analysis of Stability Measurements–Part I: Regression Control Chart," Pharmaceutical Technology 41 (11) 2017.

Monday, 8 January 2018

MTS Recommends... Data Integrity Metrics for Chromatography

Data Integrity Metrics for Chromatography

Dec 01, 2017
By Mark E. Newton, R.D. McDowall
LCGC Europe
Volume 30, Issue 12, pg 679–685

"The authors discuss metrics for monitoring data integrity within a chromatography laboratory, from the regulatory requirements to practical implementation."

Thursday, 14 December 2017

2018 Course Calendar from MTS

The MTS calendar for all our open enrolment training courses in 2018 is now available. Click here to view the calendar. Visit our course list page for more information on all the available courses.

 

Tuesday, 31 October 2017

Gradient HPLC: Is your mobile phase causing a ghost peak? Here's an easy way to find out...


Ghost peaks from mobile phase in gradient HPLC
Although not usually a problem in HPLC methods that use isocratic elution, ghost peaks resulting from the mobile phase can be a problem for gradient elution methods. Contaminants present in the mobile phase can behave like sample components and interact with the column during the gradient, leading to a ghost peak (or peaks) in the chromatogram.

However, it is easy to diagnose if your ghost peak is from the mobile phase. Simply run a blank gradient. It’s better if you can do this without performing an injection (to rule out the injection as the source of the ghost peak). In Empower, it is called ‘condition column’. If the peak is coming from the mobile phase then increasing the equilibration time at the beginning of the gradient will increase the size of the peak. For example, you could compare holding at the starting conditions for 5 minutes to holding at 10 minutes. The ghost peak will double in size if it is coming from the mobile phase.