Wednesday, 25 August 2010

MTS Recommends... ‘Holistic LC strategies, from UHPLC to HPLC and back’

Holistic LC strategies, from UHPLC to HPLC and back’ by Adrian Clarke, John Nightingale, Partha Mukherjee and Patrik Petersson in Chromatography Today, May/June 2010

One of the problems when introducing new technologies, such as UHPLC, is that although they may result in dramatic performance improvements, the methods utilised may not be easily transferred to other laboratories. In large pharma companies analytical methods may be transferred for stability studies, to contract research organisations, and to quality assurance departments, among others, and so this limits the use that can be made of a new technology. In this article, scientists at AstraZeneca describe the methods that they have used to introduce UHPLC alongside traditional HPLC techniques in a global strategy.

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